1-(5-CHLORONAPHTHALENESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE
ML-9 HYDROCHLORIDE
CAS: 105637-50-1
Molecular Formula: C15H18Cl2N2O2S
1-(5-CHLORONAPHTHALENESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE - Names and Identifiers
1-(5-CHLORONAPHTHALENESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C15H18Cl2N2O2S |
| Molar Mass | 361.29 |
| Melting Point | 196-200 |
| Solubility | ethanol: 10mg/mL |
| Appearance | powder |
| Color | white |
| Storage Condition | 2-8°C |
| Use | ML-9 is a selective potent inhibitor of Akt kinase, which inhibits the activities of myosin light chain kinase (MLCK) and matrix interacting molecule 1 (STIM1). ML-9 inhibit MLCK,PKA and PKC activities with Ki values of 4, 32 and 54 μM respectively. ML-9 induce autophagy (autophagy) by stimulating the formation of autophagosomes and inhibiting their degradation. |
1-(5-CHLORONAPHTHALENESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE - Risk and Safety
| WGK Germany | 3 |
| Hazard Note | Harmful |
1-(5-CHLORONAPHTHALENESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.768 ml | 13.839 ml | 27.679 ml |
| 5 mM | 0.554 ml | 2.768 ml | 5.536 ml |
| 10 mM | 0.277 ml | 1.384 ml | 2.768 ml |
| 5 mM | 0.055 ml | 0.277 ml | 0.554 ml |
Last Update：2024-01-02 23:10:35
1-(5-CHLORONAPHTHALENESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE - Reference Information
| biological activity | ML-9 HCl (ML-9 hydrochloride) is a potent and selective Akt kinase, myosin light chain (MLCK) and stromal interaction molecule 1 (STIM1). ML-9 HCl is also a potent inhibitor of Ca2 -permeable channels. ML-9 HCl is a lysosomal agent that targets autophagy and cell death. |
| Target | Value |
| Cell Line: | Neonatal rat ventricularmyocytes(NRVM)cells Neonatal rat ventricularmyocytes(NRVM)cells |
| Concentration: | 0, 10, 50 and 100 μM 50 μM |
| Incubation Time: | 0, 1, 4, 8 and 24 hours 1, 4 and 8 hours |
| Result: | Decreased cell viability at 50-100 μM concentration. Induced cardiomyocyte death throughnecrosisand apoptosis. |
Last Update：2024-04-09 20:52:54
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Mobile: 609-228-6898
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Tel: +86 0571-86722205
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Mobile: +86-18621343501
QQ: 2881950922
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Product Name: 1-((5-Chloronaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride Visit Supplier Webpage Request for quotationCAS: 105637-50-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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